Music
- Dave Clark (Canadian musician) was part of the band Rheostatics.
- Dave Clark (musician) was born in 1939. He was an English drummer for the Dave Clark Five and is the leader of the band.
- Dave Clark (promoter) lived from 1909 to 1995. He was an African-American record promoter and songwriter.
Politics
- David Clark, Baron Clark of Windermere (born 1939), British politician
- Dave Clark (Canadian politician), Progressive Conservative Canadian politician
- David C. Clark (1926–2015), American politician from Florida
- David M. Clark (1824–1907), American politician from Iowa
- D. Worth Clark (1902–1955), U.S. representative and senator from Idaho
- David Clark (New Zealand politician) (born 1973), Labour MP for Dunedin North since 2011
- David Clark (Georgia politician) (born 1986), Republican state representative for Georgia's 100th District
- David Clark (Utah politician) (born 1953), Republican state representative for Utah's 74th District
Sports
- Dave Clark (born 1962) is a baseball player.
- David Clark (1919–2013) was an English cricketer.
- David Clark (born 1878) was an Irish footballer.
- Dave Clark (1936–2018) was an American Olympic athlete who competed in pole vaulting.
- David Clark (born 1978) is an Australian race car driver.
- David Clark (born 1959) is an Olympic silver medal winner in rowing.
- David Clark (born 1940) was a former Australian rugby union footballer and is currently a coach.
- Dave Clarke (born 1958) is a British distance runner.
- Dave Clark was a Scottish athlete who competed in the 1990 Commonwealth Games as a sprinter.
- Dave Clark is a television presenter who works on Sky Sports.
- David K. Clark (born 1953) is a British-born jockey.
Others
- Dave Clark, a comic book superhero from the Midnight series
- David Clark (ship), a vessel used to transport convicts
- David Clark, a winner of BBC's Mastermind quiz show in 2008
- David Clark (cartoonist), an American illustrator
- David Aaron Clark (1960–2009), a performer and director in adult entertainment
- David B. Clark, a leader in the Latter Day Saint community in America
- David D. Clark (born 1944), an early pioneer in the development of the Internet in America
- David Delano Clark (1924–1997), a scientist who studied physics in America
- David H. Clark (1943–2025), an astronomer born in New Zealand who worked in Britain
- David L. Clark (1864–1939), a businessman in Pittsburgh who invented the Clark bar
- David Leigh Clark, a scientist who studies ancient life in America
- David Clark (psychiatrist) (1920–2010), a British doctor who helped improve mental health care in hospitals
- David M. Clark (born 1954), a British researcher who studies human behavior
- David W. Clark, an educator, media leader, and president of Palm Beach Atlantic University from 2003 to 2009