Arts and entertainment
- Jonathan Smith (born 1942), an English writer who writes books and plays
- Jon Robert Smith (born 1945), an American musician who plays the saxophone
- Lil Jon (Jonathan H. Smith, born 1971), an American music producer known for making rap music
- Jonny Smith (born 1979), an English television host and journalist
- Jonathan Smith, an American drummer who plays in the band Days Difference
- Jonathan Smith, also known as Jono MOFO, plays the bass guitar for the band A Place to Bury Strangers
Sports
- Jonathan Smith (American football coach) (born 1979), American college football coach and player
- Jonathan Smith (wide receiver) (born 1981), American NFL football wide receiver
- Jonathan Smith (running back) (born 1981), American football running back
- Jonathan Smith (footballer, born 1891), English player who played for QPR and Swansea Town; listed in the List of Manchester City F.C. players
- Jonathan Smith (footballer, born 1986), English footballer
- Jonathan Smith (footballer, born 1988), English footballer
- Jonny Smith (footballer) (born 1997), English footballer
- Jonathan Smith (tennis) (born 1955), British tennis player
- Jonathan Smith (rower) (born 1961), American rower
- Jonathan Smith (rugby league) (born 1979), New Zealand rugby league footballer
- Jonathan Smith (racing driver) (born 1986), American race car driver
Others
- Jonathan Bayard Smith (1742–1812), American merchant and member of the Continental Congress
- Jonathan J. Smith (1844–1916), American politician
- Jonathan Z. Smith (1938–2017), American expert in the study of religions
- Jon Michael Smith (born 1938), American scientist and engineer
- Jonathan Smith (priest) (born 1955), Church of England priest and Archdeacon of St Albans
- Jonathan Smith (games programmer) (1967–2010), British games programmer
- Jonathan Smith (psychologist), British psychology professor
- Jonathan Smith (firefighter), Commissioner of the London Fire Brigade